IONS Earnings
Wednesday, Apr 29 2026
EPS Estimate
$-0.78
$-0.96 – $-0.42
Revenue Estimate
$197M
Current Price
$74.87
Our Position
bullish · highThree drug launches in 2026 kick off triglyceride expansion
structured data
est. revisions stable
(-0.7pp / 30d)
This is a pivot from biotech volatility to near-term revenue inflection. The TRYNGOLZA traction ($108M in year one) proves market demand for triglyceride-lowering therapies exists and scales fast. Olezarsen targets severe hypertriglyceridemia, a subset of the same patient population—essentially letting Ionis double its addressable market with a single indication. The company's raised peak sales guidance to over $2 billion for the combined FCS/sHTG opportunity isn't just optimism; it's grounded in live commercial execution and a 200-rep launch team. Three approvals in one year moves Ionis from single-product risk to portfolio diversification.
Watch: The June 30 PDUFA decision for olezarsen is the near-term catalyst—a binary that could unlock peak sales ramp and validate the $2 billion market thesis. Watch the Q3 2026 earnings call for olezarsen launch uptake and revised revenue guidance; that readout will determine whether this pivot is execution-driven or optimistic.
Data Signal Summary
0 bullish
4 bearish
Estimates down -30%
Insider selling cluster
Put/call 23.2 (bearish skew)
Price downtrend
Key Context
Insider Activity
selling
Price Trend
downtrend
From 52w High
-1.4%
Est. Revisions (30d)
-30.3% 0up/2dn
Analyst Target (mean)
$97 $47–$120 +29%
Options P/C Ratio
23.23
Est. Dispersion
69% 6 analysts
Insider Cluster
strong sell
Fund Convergence
strong D.E. Shaw, Two Sigma, Citadel, Renaissance, Bridgewater
Recent Activity
insider trades
156 transactions
Sell
·
DEVERS SHANNON L (Officer)
·6,193 shares
·$458,613
Sell
·
KLEIN JOSEPH S III (Director)
·22,321 shares
·$1,686,302
Exercise
·
KLEIN JOSEPH S III (Director)
·22,321 shares
·$880,707
Sell
·
SCHNEIDER EUGENE (Officer)
·5,812 shares
·$412,486
Sell
·
HOUGEN ELIZABETH L (Chief Financial Officer)
·225,220 shares
·$16,313,676
151 more
Exercise
·
HOUGEN ELIZABETH L
·174,999 shr
·$8,989,092
Sell
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MONIA BRETT P
·160,773 shr
·$12,114,155
Exercise
·
MONIA BRETT P
·148,454 shr
·$9,039,364
Sell
·
JENNE KYLE
·37,277 shr
·$2,827,325
Exercise
·
JENNE KYLE
·37,277 shr
·$1,665,128
Sell
·
O'NEIL PATRICK R
·10,148 shr
·$763,662
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·
LOSCALZO JOSEPH
·1,032 shr
·$82,833
Exercise
·
LOSCALZO JOSEPH
·1,032 shr
·$39,278
Sell
·
BAROLDI JOSEPH
·6,659 shr
·$530,987
Exercise
·
BAROLDI JOSEPH
·2,138 shr
·$95,281
Sell
·
DEVERS SHANNON L
·20,106 shr
·$1,596,433
Exercise
·
DEVERS SHANNON L
·20,106 shr
·$723,254
Sell
·
KLEIN JOSEPH S III
·21,332 shr
·$1,696,181
Exercise
·
KLEIN JOSEPH S III
·16,000 shr
·$652,120
Sell
·
BENNETT C FRANK
·85,089 shr
·$6,741,669
Exercise
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BENNETT C FRANK
·65,089 shr
·$3,497,531
Sell
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DIAZ ALLENE M.
·54,878 shr
·$4,354,428
Exercise
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DIAZ ALLENE M.
·40,321 shr
·$1,601,607
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SWAYZE ERIC E
·15,642 shr
·$1,278,914
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PARSHALL B LYNNE
·5,000 shr
·$413,588
Sell
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MONIA BRETT P
·29,430 shr
·$2,524,820
Sell
·
BENNETT C FRANK
·85,089 shr
·$7,056,216
Sell
·
SCHNEIDER EUGENE
·6,179 shr
·$515,630
Sell
·
BIRCHLER BRIAN
·6,179 shr
·$513,048
Sell
·
MONIA BRETT P
·62,970 shr
·$5,208,979
Sell
·
BENNETT C FRANK
·5,885 shr
·$488,141
Sell
·
HOUGEN ELIZABETH L
·6,988 shr
·$581,702
Sell
·
O'NEIL PATRICK R
·6,179 shr
·$516,153
Sell
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SWAYZE ERIC E
·6,179 shr
·$512,446
Sell
·
BAROLDI JOSEPH
·5,296 shr
·$439,364
Award
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SCHNEIDER EUGENE
·11,991 shr
Award
·
BIRCHLER BRIAN
·11,991 shr
Award
·
MONIA BRETT P
·122,214 shr
Award
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BENNETT C FRANK
·11,421 shr
Award
·
HOUGEN ELIZABETH L
·13,562 shr
Award
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O'NEIL PATRICK R
·11,991 shr
Award
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SWAYZE ERIC E
·11,991 shr
Award
·
BAROLDI JOSEPH
·10,278 shr
Sell
·
DEVERS SHANNON L
·3,977 shr
·$323,490
Sell
·
SCHNEIDER EUGENE
·9,302 shr
·$703,138
Sell
·
BIRCHLER BRIAN
·8,480 shr
·$636,933
Sell
·
DEVERS SHANNON L
·8,353 shr
·$634,410
Sell
·
KORDASIEWICZ HOLLY B
·4,141 shr
·$313,308
Sell
·
MONIA BRETT P
·44,034 shr
·$3,294,624
Sell
·
BENNETT C FRANK
·8,977 shr
·$674,622
Sell
·
HOUGEN ELIZABETH L
·12,922 shr
·$971,993
Sell
·
O'NEIL PATRICK R
·9,191 shr
·$697,045
Sell
·
JENNE KYLE
·1,823 shr
·$138,475
Sell
·
SWAYZE ERIC E
·9,933 shr
·$748,383
Sell
·
BAROLDI JOSEPH
·8,056 shr
·$610,276
Other
·
SCHNEIDER EUGENE
·21,685 shr
Other
·
BIRCHLER BRIAN
·20,089 shr
Other
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DEVERS SHANNON L
·17,377 shr
Other
·
KORDASIEWICZ HOLLY B
·11,119 shr
Other
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MONIA BRETT P
·89,145 shr
Other
·
YANG MICHAEL J.
·1,930 shr
Other
·
BENNETT C FRANK
·21,055 shr
Other
·
HOUGEN ELIZABETH L
·28,729 shr
Other
·
O'NEIL PATRICK R
·21,473 shr
Other
·
JENNE KYLE
·7,013 shr
Other
·
SWAYZE ERIC E
·21,477 shr
Other
·
BAROLDI JOSEPH
·19,887 shr
Sell
·
DEVERS SHANNON L
·44,199 shr
·$3,760,577
Exercise
·
DEVERS SHANNON L
·44,199 shr
·$2,265,415
Sell
·
SWAYZE ERIC E
·23,463 shr
·$1,856,325
Exercise
·
SWAYZE ERIC E
·23,463 shr
·$1,428,662
Sell
·
WENDER JOSEPH H.
·28,000 shr
·$2,262,848
Sell
·
DEVERS SHANNON L
·16,777 shr
·$1,357,442
Exercise
·
DEVERS SHANNON L
·16,777 shr
·$902,099
Sell
·
KLEIN JOSEPH S III
·12,000 shr
·$960,000
Other
·
KLEIN JOSEPH S III
·12,000 shr
Sell
·
HERMAN JOAN E
·44,000 shr
·$3,173,830
Exercise
·
HERMAN JOAN E
·44,000 shr
·$2,525,400
Exercise
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WENDER JOSEPH H.
·16,000 shr
·$390,720
Sell
·
BIRCHLER BRIAN
·8,000 shr
·$609,379
Sell
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GEARY RICHARD S
·34,639 shr
·$2,621,816
Exercise
·
GEARY RICHARD S
·34,639 shr
·$2,045,308
Sell
·
GEARY RICHARD S
·90,929 shr
·$6,829,431
Exercise
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GEARY RICHARD S
·70,929 shr
·$4,172,678
Sell
·
LOSCALZO JOSEPH
·16,000 shr
·$1,201,669
Exercise
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LOSCALZO JOSEPH
·16,000 shr
·$835,520
Sell
·
WENDER JOSEPH H.
·28,000 shr
·$2,072,578
Sell
·
DEVERS SHANNON L
·7,263 shr
·$530,638
Sell
·
SWAYZE ERIC E
·53 shr
·$3,902
Sell
·
BIRCHLER BRIAN
·23,900 shr
·$1,723,987
Exercise
·
BIRCHLER BRIAN
·23,900 shr
·$1,285,103
Exercise
·
DEVERS SHANNON L
·8,820 shr
·$291,060
Other
·
SWAYZE ERIC E
·125 shr
Sell
·
PARSHALL B LYNNE
·5,000 shr
·$358,722
Sell
·
MONIA BRETT P
·437 shr
·$30,268
Sell
·
O'NEIL PATRICK R
·13,441 shr
·$937,338
Exercise
·
O'NEIL PATRICK R
·10,200 shr
·$539,274
Sell
·
SWAYZE ERIC E
·6,849 shr
·$472,718
Sell
·
BAROLDI JOSEPH
·1,625 shr
·$112,725
Sell
·
O'NEIL PATRICK R
·64,664 shr
·$4,377,054
Exercise
·
O'NEIL PATRICK R
·64,664 shr
·$3,813,257
Sell
·
SWAYZE ERIC E
·27,114 shr
·$1,793,744
Exercise
·
SWAYZE ERIC E
·27,114 shr
·$1,457,920
Sell
·
BAROLDI JOSEPH
·15,000 shr
·$1,020,210
Exercise
·
BAROLDI JOSEPH
·15,000 shr
·$477,000
Sell
·
WENDER JOSEPH H.
·16,800 shr
·$1,100,385
Exercise
·
GEARY RICHARD S
·57,900 shr
·$3,113,283
Sell
·
HOUGEN ELIZABETH L
·49,800 shr
·$3,249,734
Exercise
·
HOUGEN ELIZABETH L
·49,800 shr
·$2,677,746
Sell
·
GEARY RICHARD S
·57,900 shr
·$3,777,668
Sell
·
O'NEIL PATRICK R
·25,300 shr
·$1,634,921
Exercise
·
O'NEIL PATRICK R
·25,300 shr
·$1,436,534
Sell
·
O'NEIL PATRICK R
·1,700 shr
·$109,787
Exercise
·
O'NEIL PATRICK R
·1,700 shr
·$96,526
Sell
·
O'NEIL PATRICK R
·21,000 shr
·$1,355,661
Exercise
·
O'NEIL PATRICK R
·21,000 shr
·$1,274,580
Sell
·
BAROLDI JOSEPH
·11,950 shr
·$742,838
Exercise
·
BAROLDI JOSEPH
·11,950 shr
·$380,010
Sell
·
BENNETT C FRANK
·6,000 shr
·$357,581
Sell
·
BAROLDI JOSEPH
·250 shr
·$15,500
Exercise
·
BAROLDI JOSEPH
·250 shr
·$7,950
Sell
·
SCHNEIDER EUGENE
·19,658 shr
·$1,195,421
Exercise
·
SCHNEIDER EUGENE
·19,658 shr
·$1,057,011
Sell
·
DEVERS SHANNON L
·3,162 shr
·$192,943
Exercise
·
DEVERS SHANNON L
·3,162 shr
·$114,207
Sell
·
MONIA BRETT P
·203,814 shr
·$12,294,703
Exercise
·
MONIA BRETT P
·203,814 shr
·$9,032,039
Exercise
·
KLEIN JOSEPH S III
·28,000 shr
·$1,312,720
Sell
·
KLEIN JOSEPH S III
·28,000 shr
·$1,680,000
Exercise
·
KLEIN JOSEPH S III
·28,000 shr
·$1,350,080
Sell
·
BENNETT C FRANK
·51,800 shr
·$3,094,060
Exercise
·
BENNETT C FRANK
·46,800 shr
·$2,516,436
Sell
·
LOSCALZO JOSEPH
·16,000 shr
·$962,371
Exercise
·
LOSCALZO JOSEPH
·16,000 shr
·$390,720
Sell
·
O'NEIL PATRICK R
·89,900 shr
·$5,396,843
Exercise
·
O'NEIL PATRICK R
·89,900 shr
·$4,054,726
Sell
·
BAROLDI JOSEPH
·32,800 shr
·$1,946,220
Exercise
·
BAROLDI JOSEPH
·32,800 shr
·$1,043,040
Sell
·
WENDER JOSEPH H.
·28,000 shr
·$1,612,155
Sell
·
GEARY RICHARD S
·10,000 shr
·$503,671
Sell
·
SWAYZE ERIC E
·11,130 shr
·$552,862
Sell
·
PARSHALL B LYNNE
·20,000 shr
·$1,018,298
Sell
·
DIAZ ALLENE M.
·1,427 shr
·$60,687
Sell
·
BENNETT C FRANK
·10,000 shr
·$439,776
Exercise
·
BENNETT C FRANK
·10,000 shr
·$326,000
Sell
·
PARSHALL B LYNNE
·5,000 shr
·$209,646
Sell
·
GEARY RICHARD S
·10,000 shr
·$428,593
Sell
·
SCHNEIDER EUGENE
·9,549 shr
·$408,701
Sell
·
MONIA BRETT P
·2,432 shr
·$109,440
Sell
·
BAROLDI JOSEPH
·5,619 shr
·$418,953
Sell
·
BIRCHLER BRIAN
·973 shr
·$73,016
Sell
·
JENNE KYLE
·4,902 shr
·$368,488
Other
·
BAROLDI JOSEPH
·10,837 shr
Other
·
BIRCHLER BRIAN
·1,875 shr
Other
·
JENNE KYLE
·12,226 shr
Sell
·
PARSHALL B LYNNE
·5,000 shr
·$381,367
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