Mkt Cap $2B
52wk $12.53 - $48.45
14d ago
≠
We disagree with Wall Street.
Analyst consensus: bearish. Our position: bullish.
See factor model below for why.
Insider selling: $133,846,972 sold by 10 insiders (30d)
Factor divergence:
DIVERGENCE: options_sentiment bullish vs estimate_revisions, analyst_revisions bearish
Est. revisions:
-20.4%
Backed by structured data (insider trades, analyst ratings, or filings)
Factor Model (net -2.6)
Factor Model
net -2.6 5.4 / 10
Est. Revisions
-0.9
Insider Activity
+0.0
Momentum
+0.0
Analyst Rev.
-1.0
Narrative Gap
+0.0
Sionna draws $45M insider buys, Wedbush starts coverage
Watch: Phase 2a PreciSION study data expected summer 2026 will be critical to validate drug efficacy and drive next valuation step.
Insiders and firms like RA Capital and Orbimed purchased $45M shares around $18-$25, signaling strong conviction. Wedbush initiated coverage with an Outperform rating and $53 target, boosting confidence. JonesResearch raised its target to $63 after Phase 2a PreciSION enrollment completion; data expected summer 2026. Despite insider selling pressure, multiple buyers suggest bullish institutional view amid a 12% price dip from 52-week high.
The strong insider and institutional buying combined with analyst upgrades signals growing confidence in Sionna's biotech pipeline and upcoming clinical readouts, likely supporting a re-rate in valuation and share price.
Evidence
5d ago
Citizens reit SION: Market Outperform → Market Outperform
11d ago
Freedom Broker down SION: Buy → Hold
13d ago
Stifel main SION: Buy → Buy
15d ago
Insider sell by THOMPSON PETER A (SION): $13,364,064
15d ago
Insider sell by RA CAPITAL HEALTHCARE FUND,L.P. (SION): $14,762,604
15d ago
Insider sell by ORBIMED ADVISORS, L.L.C. (SION): $13,364,064
15d ago
Insider sell by ORBIMED ADVISORS, L.L.C. (SION): $22,945,044
15d ago
Insider buy by TPG GP A LLC (SION): $20,250,000
7 older signals
15d ago
Insider buy by TPG GP A, L.L.C. (SION): $20,250,000
15d ago
Insider sell by THOMPSON PETER A (SION): $22,945,044
15d ago
Insider buy by ATLAS VENTURE FUND XI L.P (SION): $1,080,000
15d ago
Insider buy by RA CAPITAL MANAGEMENT, L.P. (SION): $20,250,000
15d ago
Insider sell by TPG GP A, L.L.C. (SION): $10,000,000
15d ago
Insider buy by ORBIMED ADVISORS, L.L.C. (SION): $9,900,000
15d ago
Insider buy by THOMPSON PETER A (SION): $13,750,000
Fundamentals & Data ▾
Sionna Therapeutics, Inc.
Healthcare · Biotechnology
Mkt Cap
$2B
52w Range
$12.53 - $48.45
Short Interest
4.2M 15.22%
Days to Cover
9.3 +13%
Technicals
downtrend
from 52w Hi
-6.7%
1w return
+9.3%
Insiders
selling
0B / 17S
Analysts
bearish
0 up / 1 down
EPS Estimate
$-0.64
-20.4% 30d
0up / 6dn
Est. Dispersion
12%
9 analysts
Analyst Target
$52
$23 - $63
Options P/C
2.00
Insider Cluster
strong buy
6B / 8S
Fund Convergence
strong
Elliott, Citadel, D.E. Shaw
Top Holders
Elliott
$131M
Citadel
$45M
D.E. Shaw
$2M
Recent Filings & Data
insider trade
47
net selling
· $133,846,972 sold
· $87,380,800 bought
10 insiders · 47 transactions (30d)
Recent transactions
THOMPSON PETER A · other
THOMPSON PETER A · sell · $13,364,064
ORBIMED ADVISORS, L.L.C. · sell · $13,364,064
THOMPSON PETER A · sell · $2,472,343
ORBIMED ADVISORS, L.L.C. · sell · $2,472,343
THOMPSON PETER A · sell · $22,945,044
ORBIMED ADVISORS, L.L.C. · sell · $22,945,044
FITZPATRICK JENNIFER R · sell · $347,019
FITZPATRICK JENNIFER R · exercise · $62,628
THOMPSON PETER A · sell · $1,379,866
ORBIMED ADVISORS, L.L.C. · sell · $1,379,866
TPG GP A, L.L.C. · sell · $10,000,000
THOMPSON PETER A · sell · $1,486,010
ORBIMED ADVISORS, L.L.C. · sell · $1,486,010
THOMPSON PETER A · sell · $83,428
ORBIMED ADVISORS, L.L.C. · sell · $83,428
FITZPATRICK JENNIFER R · sell · $415,330
THOMPSON PETER A · sell · $4,814,205
ORBIMED ADVISORS, L.L.C. · sell · $4,814,205
RA CAPITAL MANAGEMENT, L.P. · sell · $1,200,704
RA CAPITAL MANAGEMENT, L.P. · sell · $5,500,158
RA CAPITAL HEALTHCARE FUND,L.P. · sell · $14,762,604
CLOONAN MICHAEL · sell · $3,618,560
CLOONAN MICHAEL · exercise · $609,778
CLOONAN MICHAEL · sell · $788,153
CLOONAN MICHAEL · exercise · $153,972
CLOONAN MICHAEL · sell · $727,798
CLOONAN MICHAEL · exercise · $152,750
FITZPATRICK JENNIFER R · sell · $236,980
RIDLOFF ELENA · sell · $240,442
RIDLOFF ELENA · sell · $601,858
CLOONAN MICHAEL · sell · $624,361
CLOONAN MICHAEL · sell · $568,750
RIDLOFF ELENA · sell · $1,124,335
TPG GP A, L.L.C. · buy · $950,400
TPG GP A LLC · buy · $950,400
THOMPSON PETER A · buy · $13,750,000
TPG GP A, L.L.C. · other
TPG GP A LLC · buy · $20,250,000
TPG GP A LLC · other
ORBIMED ADVISORS, L.L.C. · buy · $9,900,000
ORBIMED ADVISORS, L.L.C. · other
RA CAPITAL MANAGEMENT, L.P. · buy · $20,250,000
RA CAPITAL MANAGEMENT, L.P. · other
ATLAS VENTURE FUND XI L.P · buy · $1,080,000
ATLAS VENTURE FUND XI L.P · other
TPG GP A, L.L.C. · buy · $20,250,000
analyst rating
1
Freedom Broker
down
→ Hold
11d ago
15 signals · latest 5d ago
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