Get emailed when QURE changes direction
Insider selling: $17,507,876 sold by 14 insiders (30d)
Est. revisions:
-0.5%
(1 up, 0 down in 30d)
Backed by structured data (insider trades, analyst ratings, or filings)
Factor Model (net +1.4)
Factor Model
net +1.4 3.2 / 10
Est. Revisions
-0.0
Insider Activity
+0.0
Momentum
+0.0
Analyst Rev.
+1.0
Narrative Gap
+0.0
FDA demands pivotal study, pushing gene therapy timeline out
Watch: Watch for management's response on study design, timeline, and cash runway. Any guidance on trial start date or financing plans will clarify whether the program remains viable.
UniQure stock cratered 32% on March 2 after US regulators demanded a pivotal study before approving its Huntington's disease gene therapy. The requirement wasn't anticipated and pushes potential market approval out by years. No details yet on study design, enrollment timeline, or what specific safety or efficacy gaps the FDA wants addressed.
This is a clinical and commercial setback that resets the approval clock. Gene therapy trials are expensive, slow, and carry execution risk — the company now faces years of added cash burn before any revenue from its lead program.
Evidence
2d ago
Goldman Sachs main QURE: Neutral → Neutral
44d ago
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Fundamentals & Data ▾
uniQure N.V.
Healthcare · Biotechnology
Mkt Cap
$1B
Beta
0.75
52w Range
$8.73 - $71.50
Short Interest
11.0M 17.77%
Days to Cover
2.3 -13%
Technicals
downtrend
from 52w Hi
-3.3%
1w return
+2.1%
Insiders
selling
0B / 15S
Analysts
mixed
EPS Estimate
$-0.75
-0.5% 30d
1up / 0dn
Est. Dispersion
33%
9 analysts
Analyst Target
$39
$9 - $96
Options P/C
9.29
Insider Cluster
strong sell
0B / 10S
Fund Convergence
moderate
Citadel, Two Sigma
Financials
Revenue
$6M +7% YoY
FCF
$-78M
Gross Margin
92%
Op Margin
-925%
Momentum:
accelerating
Top Holders
Citadel
$42M
Two Sigma
$27M
Recent Filings & Data
insider trade
80
net selling
· $17,507,876 sold
14 insiders · 80 transactions (30d)
Recent transactions
KAPUSTA MATTHEW C · award
KAPUSTA MATTHEW C · sell · $132,104
KLEMT CHRISTIAN · award
KLEMT CHRISTIAN · sell · $108,720
POTTS JEANNETTE · award
POTTS JEANNETTE · sell · $30,913
ABI-SAAB WALID · award
ABI-SAAB WALID · sell · $7,320
O'KEEFE KYLIE · award
KAPUSTA MATTHEW C · sell · $342,648
KLEMT CHRISTIAN · sell · $124,693
POTTS JEANNETTE · sell · $85,351
ABI-SAAB WALID · sell · $16,517
KAPUSTA MATTHEW C · sell · $295,339
KLEMT CHRISTIAN · sell · $148,338
GUT ROBERT · sell · $630,483
GUT ROBERT · exercise · $250,765
KAYE JACK · sell · $174,319
KAYE JACK · exercise · $123,902
GUT ROBERT · sell · $856,881
GUT ROBERT · exercise · $72,389
KAYE JACK · sell · $1,177,517
KAYE JACK · exercise · $383,535
KLEMT CHRISTIAN · sell · $945,120
KLEMT CHRISTIAN · exercise · $119,640
KAPUSTA MATTHEW C · sell · $9,382,473
KAPUSTA MATTHEW C · exercise · $1,474,909
ABI-SAAB WALID · sell · $20,407
MEEK DAVID D · sell · $30,518
GUT ROBERT · sell · $48,205
BALACHANDRAN MADHAVEN · sell · $30,518
POST LEONARD E · sell · $30,518
KAYE JACK · sell · $30,518
SPRINGHORN JEREMY P · sell · $30,518
JACQUES RACHELLE SUZANNE · sell · $30,518
POTTS JEANNETTE · sell · $70,704
MEEK DAVID D · award
GUT ROBERT · award
BALACHANDRAN MADHAVEN · award
POST LEONARD E · award
KAYE JACK · award
SPRINGHORN JEREMY P · award
JACQUES RACHELLE SUZANNE · award
KAPUSTA MATTHEW C · sell · $291,629
KLEMT CHRISTIAN · sell · $107,407
POTTS JEANNETTE · sell · $72,812
ABI-SAAB WALID · sell · $13,892
KAPUSTA MATTHEW C · award
KLEMT CHRISTIAN · award
POTTS JEANNETTE · award
ABI-SAAB WALID · award
KAPUSTA MATTHEW C · sell · $362,015
KLEMT CHRISTIAN · sell · $186,458
KAPUSTA MATTHEW C · award
KLEMT CHRISTIAN · award
KAPUSTA MATTHEW C · sell · $1,503,000
KAPUSTA MATTHEW C · exercise · $1,471,000
KAPUSTA MATTHEW C · sell · $26,079
KLEMT CHRISTIAN · sell · $13,560
KAPUSTA MATTHEW C · award
KLEMT CHRISTIAN · award
ABI-SAAB WALID · sell · $6,309
MEEK DAVID D · award
GUT ROBERT · award
BALACHANDRAN MADHAVEN · award
POST LEONARD E · award
KAYE JACK · award
SPRINGHORN JEREMY P · award
JACQUES RACHELLE SUZANNE · award
KLEMT CHRISTIAN · sell · $7,733
ALAIN PIERRE CALOZ · sell · $14,122
MEEK DAVID D · sell · $11,412
SOTEROPOULOS PAULA · sell · $11,411
GUT ROBERT · sell · $17,940
BALACHANDRAN MADHAVEN · sell · $11,423
POST LEONARD E · sell · $11,421
KAYE JACK · sell · $11,445
SPRINGHORN JEREMY P · sell · $11,423
JACQUES RACHELLE SUZANNE · sell · $11,416
POTTS JEANNETTE · sell · $23,809
4 signals · latest 2d ago
Get alerted when QURE changes direction
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