HRMY Harmony Biosciences Holdings, Inc.

bullish track record → $29.53 -0.46 (-1.5%)
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Mkt Cap $2B P/E 10.7 fwd 5.1 52wk $25.52 - $40.87 Earnings 2026-05-05 46d ago
Insider selling: $429,995,371 sold by 9 insiders (30d)
Factor divergence: DIVERGENCE: estimate_revisions bullish vs analyst_revisions bearish
Est. revisions: +7.9%
Backed by structured data (insider trades, analyst ratings, or filings)
Factor Model (net -0.5)

Factor Model

net -0.5 2.2 / 10
Est. Revisions
+0.5
Insider Activity
+0.0
Momentum
+0.0
Analyst Rev.
-1.0
Narrative Gap
+0.0

WAKIX revenue hits $868M, $1B blockbuster status looms

Watch: Watch Q1 2026 patient additions and guidance for 2026 revenue. If the 400-patient-per-quarter pace holds and management affirms $1B+ revenue outlook, the Hold rating likely shifts—Deutsche Bank's recent target cut to $30 from $31 suggests limited upside in their view, but blockbuster confirmation could flip sentiment.

Harmony Biosciences delivered solid Q4 2025 results with WAKIX revenue of $243.8 million, up 21% year-over-year, capping a full year at $868.5 million. Patient adds remain consistent—roughly 400 per quarter for three straight quarters, bringing the total patient base to ~8,500. The trajectory puts WAKIX on pace to cross $1 billion in revenue and achieve blockbuster status in 2026.

Six consecutive years of revenue growth and steady patient adoption prove WAKIX has durability beyond launch hype. Hitting blockbuster status next year would validate the franchise's competitive moat in narcolepsy and establish HRMY as a sustainable revenue generator, not a one-hit wonder riding a single indication.

Evidence

7d ago Insider sell by VALOR IV PHARMA HOLDINGS L.L.C. (HRMY): $139,391,500
7d ago Insider sell by MARSHMAN FUND TRUST II (HRMY): $139,391,500
7d ago Insider sell by VALOR EQUITY PARTNERS (HRMY): $139,391,500
46d ago Deutsche Bank Lifts PT on Monster Beverage Corporation (MNST) to $88 From $84 yahoo-finance
49d ago Deutsche Bank Cuts PT on Harmony Biosciences Holdings (HRMY) to $30 From $31 yahoo-finance
Fundamentals & Data ▾
Harmony Biosciences Holdings, Inc. Healthcare · Biotechnology
Mkt Cap
$2B
P/E
10.7 fwd 5.1
Beta
0.89
52w Range
$25.52 - $40.87
Short Interest
7.6M 28.66%
Days to Cover
5.6 +41%
Technicals downtrend
from 52w Hi
0.0%
1w return
+3.8%
Insiders
selling 0B / 7S
EPS Estimate
$1.00 +7.9% 30d 0up / 2dn
Est. Dispersion
48% 4 analysts
Analyst Target
$42 $25 - $62
Options P/C
0.15
Insider Cluster
strong sell 0B / 5S
Fund Convergence
strong Renaissance, Citadel, Bridgewater, Two Sigma, D.E. Shaw
Financials
Revenue
$244M +21% YoY
FCF
$126M
Gross Margin
72%
Op Margin
16%
Momentum: decelerating
Top Holders
Renaissance $40M
Citadel $19M
Bridgewater $9M
Two Sigma $4M
D.E. Shaw
Recent Filings & Data
insider trade 50
net selling · $429,995,371 sold
9 insiders · 50 transactions (30d)
Recent transactions
ZAESKE ADAM H. · other
KAPADIA SANDIP S. · sell · $139,171
DAYNO JEFFREY M · other
KAPADIA SANDIP S. · other
SERAFIN ANDREW · other
BUDUR KUMAR · other
KAPADIA SANDIP S. · sell · $752,833
DAYNO JEFFREY M · sell · $1,040,103
DAYNO JEFFREY M · exercise · $164,400
KAPADIA SANDIP S. · sell · $790,896
KAPADIA SANDIP S. · exercise · $580,600
KAPADIA SANDIP S. · sell · $119,945
KAPADIA SANDIP S. · other
KAPADIA SANDIP S. · sell · $787,378
BUDUR KUMAR · other
KAPADIA SANDIP S. · sell · $227,386
KAPADIA SANDIP S. · other
DIERKS JEFFREY G · sell · $159,090
DIERKS JEFFREY G · exercise · $40,023
KAPADIA SANDIP S. · sell · $67,547
DIERKS JEFFREY G · sell · $551,575
DAYNO JEFFREY M · other
KAPADIA SANDIP S. · other
DIERKS JEFFREY G · exercise · $402,806
SERAFIN ANDREW · other
BUDUR KUMAR · other
DAYNO JEFFREY M · sell · $774,245
DAYNO JEFFREY M · exercise · $158,588
KAPADIA SANDIP S. · sell · $1,004,598
KAPADIA SANDIP S. · exercise · $725,750
DIERKS JEFFREY G · sell · $1,147,715
DIERKS JEFFREY G · exercise · $1,023,197
DIERKS JEFFREY G · sell · $388,841
DIERKS JEFFREY G · exercise · $351,354
DIERKS JEFFREY G · sell · $265,946
DIERKS JEFFREY G · exercise · $240,099
VALOR EQUITY PARTNERS · sell · $139,391,500
MARSHMAN FUND TRUST II · sell · $139,391,500
VALOR IV PHARMA HOLDINGS L.L.C. · sell · $139,391,500
DIERKS JEFFREY G · sell · $870,018
DIERKS JEFFREY G · exercise · $515,904
DIERKS JEFFREY G · sell · $1,274,547
DIERKS JEFFREY G · sell · $16,077
DIERKS JEFFREY G · exercise · $9,600
KAPADIA SANDIP S. · other
DIERKS JEFFREY G · sell · $1,434,951
DIERKS JEFFREY G · exercise · $860,304
DIERKS JEFFREY G · other
DIERKS JEFFREY G · sell · $8,009
DIERKS JEFFREY G · exercise · $4,800
5 signals · latest 7d ago

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