CAI Caris Life Sciences, Inc.

bullish track record → $21.15 +0.75 (+3.7%)
Get emailed when CAI changes direction
Mkt Cap $5B 52wk $16.28 - $42.50 Earnings 2026-05-05 46d ago
Insider selling: $1,654,461 sold by 14 insiders (30d)
Est. revisions: +37.5%
Backed by structured data (insider trades, analyst ratings, or filings)
Factor Model (net +1.7)

Factor Model

net +1.7 2.8 / 10
Est. Revisions
+1.0
Insider Activity
+0.0
Momentum
+0.0
Analyst Rev.
+0.0
Narrative Gap
+0.0

CAI Launches AI Breast Cancer Prediction Feature

Watch: Monitor uptake and reimbursement coverage for the new breast cancer signature — clinical labs and oncologists must order it for the revenue story to materialize. Watch for FDA clearance or breakthrough designation announcements for other solid-tumor signatures, which would validate the AI platform's scalability.

Caris Life Sciences rolled out a new AI-powered breast cancer signature within its Caris Molecular Tumor Board Report on February 24, 2026. The tool predicts treatment response to capecitabine in HER2-negative patients using data from over 2,000 gene expression samples. The company's MI Cancer Seek platform — which combines Whole Exome Sequencing and Whole Transcriptome Sequencing — earned FDA approval in November 2024, and this AI expansion reinforces its position in precision oncology diagnostics. The new 'Caris AI Insights' section also identifies tissue of origin and assesses metastasis risk.

This move extends CAI's competitive moat in molecular testing by adding predictive AI that guides personalized treatment decisions — a direct revenue lever in a consolidating oncology diagnostics market. AI-powered decision support is becoming table stakes for labs; CAI's trained models on 2,000+ samples give it a material data advantage in a sector where clinical validation drives adoption and pricing power.

Evidence

7d ago Insider buy by BRILLE BRIAN J. (CAI): $817,500
7d ago Insider buy by SPETZLER DAVID BAXLEY PH.D. (CAI): $9,540
7d ago Insider buy by DENTON JOHN RUSSEL (CAI): $100,793
7d ago Jefferies init CAI: Buy
7d ago Insider buy by DENTON JOHN RUSSEL (CAI): $204,375
Fundamentals & Data ▾
Caris Life Sciences, Inc. Healthcare · Biotechnology
Mkt Cap
$5B
52w Range
$16.28 - $42.50
Short Interest
7.5M 5.17%
Days to Cover
3.2 +24%
Technicals downtrend
from 52w Hi
0.0%
1w return
+17.2%
Insiders
buying 3B / 0S
Analysts
bullish 1 up / 0 down
EPS Estimate
$-0.02 +37.5% 30d 0up / 0dn
Est. Dispersion
536% 8 analysts
Analyst Target
$30 $21 - $38
Options P/C
0.31
Insider Cluster
strong buy 3B / 1S (officer)
Fund Convergence
strong Coatue, Citadel, Renaissance
Financials
Revenue
$293M
FCF
$40M
Gross Margin
75%
Op Margin
30%
Momentum: accelerating
Top Holders
Coatue $265M
Citadel $86M
Renaissance $9M
Recent Filings & Data
insider trade 34
net selling · $1,654,461 sold · $1,132,208 bought
14 insiders · 34 transactions (30d)
Recent transactions
HALBERT DAVID D · award
BRILLE BRIAN J. · award
DENTON JOHN RUSSEL · award
POWER LUKE THOMAS · award
SPETZLER DAVID BAXLEY PH.D. · award
CASTLEMAN PETER M · award · $110,511
VACIRCA JEFF L · award · $49,990
MINOR LLOYD B. · award · $49,990
HALBERT JON S. · award · $49,990
PHILLIPS T DANNY · award · $75,004
FREDRICKSON DAVID PAUL · award · $49,990
CASTLEMAN PETER M · exercise · $46,500
BRILLE BRIAN J. · other
POWER LUKE THOMAS · sell · $1,654,461
POWER LUKE THOMAS · exercise · $151,890
DENTON JOHN RUSSEL · buy · $100,793
SPETZLER DAVID BAXLEY PH.D. · buy · $9,540
PHILLIPS T DANNY · exercise · $244,000
POSTE GEORGE H · exercise · $305,000
HALBERT DAVID D · other
CASTLEMAN PETER M · other
TSSP SUB-FUND HOLDCO, L.L.C. · other
BRILLE BRIAN J. · buy · $817,500
HALBERT JON S. · other
DENTON JOHN RUSSEL · buy · $204,375
SPETZLER DAVID BAXLEY PH.D. · exercise · $183,000
ADAPT I LTD · other
HALBERT DAVID D · award
BRILLE BRIAN J. · award
DENTON JOHN RUSSEL · award
POWER LUKE THOMAS · award
SPETZLER DAVID BAXLEY PH.D. · award
CASTLEMAN PETER M · other
HALBERT JON S. · other
analyst rating 1
Jefferies init → Buy 7d ago
8 signals · latest 7d ago

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